Tag Archives: Evidence-Based Medicine

Drug safety in a world of multimorbidity and polypharmacy

New research describes an association between use of two commonly used medications and brain haemorrhage. CCHSR’s Rupert Payne doesn’t necessarily think it’s that straightforward.

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Multi-morbidity and the Emperor’s New Clothes: a challenge for primary care researchers

Are single disease guidelines and indicators are going out of fashion? Well they are with people interested in multi-morbidity. The argument is straightforward. Single disease guidelines are usually based on trials which exclude people with multiple complex problems. So how does the physician know how a cholesterol guideline developed from trials on 65 year old …read more

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Why has the Welsh government approved Sativa for multiple sclerosis and not NICE in England?

Sativa is a nasal spray based on a cannabis extract which is used for painful muscle cramps in multiple sclerosis. There doesn’t seem much doubt that it works, and in its most recent draft guidance on MS, NICE has based it’s decision on cost effectiveness grounds – the benefit came out at £49,300 per QALY …read more

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mH2 – the future of mental healthcare

Mental healthcare is often described as the Cinderella of medicine – overlooked, disparaged, and generally neglected. In the UK, mental healthcare is the single biggest item on the NHS budget (£12.16bn in 2010/11), but in practice this means that only about 11% of the overall spend is allocated to deal with 23% of the disease …read more

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Medicalising life

Medicines have been getting into the mainstream news quite a lot in recent times. A couple of days ago saw the publication in Annals of Oncology of a review of the evidence for a protective effect of aspirin in reducing cancer in the general population. The role of aspirin in cardiovascular disease prevention is well …read more

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Keeping Cochrane reviews up-to-date

The Cochrane Collaboration is an organisation that conducts systematic reviews of healthcare interventions.  The idea is that they are updated periodically (every 2 years) so that they provide the best evidence on what works and what doesn’t. After 21 years of existence, the Cochrane Library now holds over 6000 reviews by some 20,000 volunteer authors.  …read more

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Mr Hunt goes mad about the French

This week we had the unusual sight of an English Secretary of State for Health going over to France to get ideas about how to run our health services. It was all about dementia, and apparently the French are much better about diagnosing dementia than we are (perhaps because they have more neurologists). However, the …read more

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A symple lesson?

Hypertension is a huge public health problem, and contributes significantly to the development of cardiovascular disease. The mainstays of treatment are lifestyle measures and a range of common pharmacological agents such as ACE inhibitors, calcium channel blockers and diuretics. The general approach to managing hypertension is, the lower the blood pressure, the better. However, a …read more

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Medication safety and the real world of general practice

Clinical trials are carefully designed to establish the efficacy and safety of new drugs. But how relevant are they to the real-world setting of general practice? And what can general practice do to try and help research into drug safety?

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Inappropriate medicines and prescribing – why it matters

Over the last year, the English NHS spent £10 billion on prescribing around a billion items in primary care. Yet a substantial amount of medication use may be potentially inappropriate. How can we as researchers potentially address this problem?

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  • The Cambridge Centre for Health Services Research (CCHSR) is a thriving collaboration between the University of Cambridge and RAND Europe. We aim to inform health policy and practice by conducting research and evaluation studies of organisation and delivery of healthcare, including safety, effectiveness, efficiency and patient experience.